FAM225A facilitates colorectal cancer progression by sponging miR-613 to regulate NOTCH3.

ABSTRACT: Colorectal cancer (CRC) is a fatal disease ranking the third among the commonplace cancer types around the world. It is extremely significant to exploit effective treatments against CRC. FAM225A was proved to influence cell progression and forecast unfavorable prognosis in nasopharyngeal carcinoma. The role and function mechanism of FAM225A are still unclear in CRC. In this research, FAM225A was discovered presenting much higher expression in CRC tissues and cell lines. In addition, depleting FAM225A was capable of inhibiting cell proliferation, migration, and epithelial-to-mesenchymal transition (EMT) progress, and enhancing cell apoptosis ability. Furthermore, miR-613 exerted important effects as a mediator between FAM225A and NOTCH3. NOTCH3 was negatively correlated with miR-613, wherea

SUBMITTER: Zhang X 

PROVIDER: S-EPMC7300395 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature