Prognostic and predicted significance of Ubqln2 in patients with hepatocellular carcinoma.

ABSTRACT:

Purpose

Hepatocellular carcinoma (HCC) is a common malignant cancer and the third leading cause of death worldwide. The molecular mechanism of HCC remains unclear. Recent studies have demonstrated that the ubiquitin-proteasome system (UPS) is associated with HCC. Ubqln2, a member of the UPS, is abnormally expressed in HCC. However, whether Ubqln2 is associated with HCC prognosis remains unknown.

Patients and methods

We analyzed the associations between overall survival and various risk factors in 355 HCC tissue samples obtained from the Cancer Genomic Atlas (TCGA) database at the mRNA level and in 166 HCC tissue samples from Southwest Hospital at the protein level. qRCR was used to determinate Ubqln2 expression in cancer and noncancerous tissues. The association between Ubql

SUBMITTER: Luo YD 

PROVIDER: S-EPMC7300399 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature