Molecular Alterations Prompted by SARS-CoV-2 Infection: Induction of Hyaluronan, Glycosaminoglycan and Mucopolysaccharide Metabolism.

ABSTRACT:

Background

The SARS-CoV-2 is the etiological agent causing COVID-19 which has infected more than 2 million people with more than 200000 deaths since its emergence in December 2019. In the majority of cases patients are either asymptomatic or show mild to moderate symptoms and signs of a common cold. A subset of patients, however, develop a severe atypical pneumonia, with the characteristic ground-glass appearance on chest x-ray and computerized tomography, which evolves into an acute respiratory distress syndrome, that requires mechanical ventilation and eventually results in multiple organ failure and death. The Molecular pathogenesis of COVID-19 is still unknown.

Aim of the study

In the present work we performed a stringent metanalysis from the publicly available RNAseq da

SUBMITTER: Andonegui-Elguera S 

PROVIDER: S-EPMC7301110 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature