OFC and its connectivity with amygdala as predictors for future social anxiety in adolescents.

ABSTRACT: Social anxiety is a common problem that usually emerges at puberty, during which great developmental changes occur both in the brain and mental state. However, little is known about the influence of social anxiety on adolescents' brain and behavior. The present study investigated the neural basis of social anxiety using voxel-based morphometry (VBM) and functional connectivity analysis. Then we investigated whether social anxiety is associated with attention bias. Furthermore, we investigated the neural basis of this association. Finally, longitudinal data was used to test if these biomarkers could predict social anxiety. The results indicated that social anxiety is positively associated with the grey matter volume (GMV) of orbital-frontal cortex (OFC), and the functional connectivity (FC)

SUBMITTER: Mao Y 

PROVIDER: S-EPMC7301179 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature