Theranostic markers for personalized therapy of spider phobia: Methods of a bicentric external cross-validation machine learning approach.

ABSTRACT:

Objectives

Embedded in the Collaborative Research Center "Fear, Anxiety, Anxiety Disorders" (CRC-TRR58), this bicentric clinical study aims at identifying biobehavioral markers of treatment (non-)response by applying machine learning methodology with an external cross-validation protocol. We hypothesize that a priori prediction of treatment (non-)response is possible in a second, independent sample based on multimodal markers.

Methods

One-session virtual reality exposure treatment (VRET) with patients with spider phobia was conducted on two sites. Clinical, neuroimaging, and genetic data were assessed at baseline, post-treatment and after 6 months. The primary and secondary outcomes defining treatment response are as follows: 30% reduction regarding the individual score in t

SUBMITTER: Schwarzmeier H 

PROVIDER: S-EPMC7301283 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature