Stability of mismatch negativity event-related potentials in a multisite study.

ABSTRACT:

Objectives

Mismatch negativity (MMN), an auditory event-related potential sensitive to deviance detection, is smaller in schizophrenia and psychosis risk. In a multisite study, a regression approach to account for effects of site and age (12-35 years) was evaluated alongside the one-year stability of MMN.

Methods

Stability of frequency, duration, and frequency + duration (double) deviant MMN was assessed in 167 healthy subjects, tested on two occasions, separated by 52 weeks, at one of eight sites. Linear regression models predicting MMN with age and site were validated and used to derive standardized MMN z-scores. Variance components estimated for MMN amplitude and latency measures were used to calculate Generalizability (G) coefficients within each site to assess MMN stabi

SUBMITTER: Roach BJ 

PROVIDER: S-EPMC7301288 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature