Effects of Obstructive Sleep Apnea and Obesity on Morphine Pharmacokinetics in Children.

ABSTRACT:

Background

Obesity increases susceptibility to chronic pain, increases metabolism, and is associated with obstructive sleep apnea syndrome (OSAS), all which can complicate perioperative pain management of patients. In addition, obesity and OSAS can cause elevation of the adipose-derived hormone leptin, which increases metabolism. We hypothesized that obesity along with sleep apnea and leptin independently enhance morphine pharmacokinetics.

Methods

Children 5-12 years of age who were presenting for surgery were administered a morphine dose of 0.05 mg/kg. Blood was collected at baseline and at subsequent preset times for pharmacokinetic analysis of morphine and its metabolites. Three groups were studied: a nonobese group with severe OSAS, an obese group with severe OSAS, and a

SUBMITTER: Dalesio NM 

PROVIDER: S-EPMC7301293 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature