Delving into Eukaryotic Origins of Replication Using DNA Structural Features.

ABSTRACT: DNA replication in eukaryotes is an intricate process, which is precisely synchronized by a set of regulatory proteins, and the replication fork emanates from discrete sites on chromatin called origins of replication (Oris). These spots are considered as the gateway to chromosomal replication and are stereotyped by sequence motifs. The cognate sequences are noticeable in a small group of entire origin regions or totally absent across different metazoans. Alternatively, the use of DNA secondary structural features can provide additional information compared to the primary sequence. In this article, we report the trends in DNA sequence-based structural properties of origin sequences in nine eukaryotic systems representing different families of life. Biologically relevant DNA secondary struct

SUBMITTER: Yella VR 

PROVIDER: S-EPMC7301376 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature