Interference chromatography: a novel approach to optimizing chromatographic selectivity and separation performance for virus purification.

ABSTRACT:

Background

Oncolytic viruses are playing an increasingly important role in cancer immunotherapy applications. Given the preclinical and clinical efficacy of these virus-based therapeutics, there is a need for fast, simple, and inexpensive downstream processing methodologies to purify biologically active viral agents that meet the increasingly higher safety standards stipulated by regulatory authorities like the Food and Drug Administration and the European Agency for the Evaluation of Medicinal Products. However, the production of virus materials for clinical dosing of oncolytic virotherapies is currently limited-in quantity, quality, and timeliness-by current purification technologies. Adsorption of virus particles to solid phases provides a convenient and practical choice for lar

SUBMITTER: Santry LA 

PROVIDER: S-EPMC7301511 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature