Stakeholder perspectives on adaptive clinical trials: a scoping review.

ABSTRACT:

Background

Adaptive clinical trials (ACTs) represent an emerging approach to trial design where accumulating data are used to make decisions about future conduct. Adaptations can include comparisons of multiple dose tiers, response-adaptive randomization, sample size re-estimation, and efficacy/futility stopping rules. The objective of this scoping review is to assess stakeholder attitudes, perspectives, and understanding of adaptive trials.

Methods

We conducted a review of articles examining stakeholders encompassing the broad medical trial community's perspectives of adaptive designs (ADs). A computerized search was conducted of four electronic databases with relevant search terms. Following screening of articles, the primary findings of each included article were coded fo

SUBMITTER: Madani Kia T 

PROVIDER: S-EPMC7301522 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature