Isolation of Coxiella burnetii in patients with nonspecific febrile illness in South Korea.

ABSTRACT:

Background

The number of human Q fever cases in South Korea has been rapidly increasing since 2015. We report the first isolation of Coxiella burnetii in Korea in two patients who initially presented with non-specific febrile illness and were finally diagnosed with acute Q fever in South Korea.

Case presentation

Two adult patients with fever had serologic tests against C. burnetii initially negative, and polymerase chain reaction against 16S rRNA using whole blood was also negative. After bacterial amplification of C. burnetii in immune-depressed mice, we isolated C. burnetii from patients with acute Q fever. The isolates KZQ2 and KZQ3 were confirmed by polymerase chain reaction, nucleotide sequence analysis, and morphologic observation using a transmission electron microsco

SUBMITTER: Lee SH 

PROVIDER: S-EPMC7301556 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature