Pax7 as molecular switch regulating early and advanced stages of myogenic mouse ESC differentiation in teratomas.

ABSTRACT:

Background

Pluripotent stem cells present the ability to self-renew and undergo differentiation into any cell type building an organism. Importantly, a lot of evidence on embryonic stem cell (ESC) differentiation comes from in vitro studies. However, ESCs cultured in vitro do not necessarily behave as cells differentiating in vivo. For this reason, we used teratomas to study early and advanced stages of in vivo ESC myogenic differentiation and the role of Pax7 in this process. Pax7 transcription factor plays a crucial role in the formation and differentiation of skeletal muscle precursor cells during embryonic development. It controls the expression of other myogenic regulators and also acts as an anti-apoptotic factor. It is also involved in the formation and maintenance of satell

SUBMITTER: Florkowska A 

PROVIDER: S-EPMC7301568 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature