Associations between voxel-level accumulated dose and rectal toxicity in prostate radiotherapy.

ABSTRACT:

Background and purpose

Associations between dose and rectal toxicity in prostate radiotherapy are generally poorly understood. Evaluating spatial dose distributions to the rectal wall (RW) may lead to improvements in dose-toxicity modelling by incorporating geometric information, masked by dose-volume histograms. Furthermore, predictive power may be strengthened by incorporating the effects of interfraction motion into delivered dose calculations.Here we interrogate 3D dose distributions for patients with and without toxicity to identify rectal subregions at risk (SRR), and compare the discriminatory ability of planned and delivered dose.

Material and methods

Daily delivered dose to the rectum was calculated using image guidance scans, and accumulated at the voxel level usin

SUBMITTER: Shelley LEA 

PROVIDER: S-EPMC7301619 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature