Associations between IL-6 Variations and Congenital Heart Disease Incidence among Chinese Han People.

ABSTRACT: BACKGROUND Our research explored if Interleukin-6 (IL-6) variants held substantial connection to congenital heart disease (CHD) susceptibility among Chinese Han children. MATERIAL AND METHODS A total of 102 CHD children were recruited as the case group while 98 healthy persons were recruited as the control group. We used polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) completed genotyping for IL-6 variants rs1800795 and rs1800796. The Hardy-Weinberg equilibrium (HWE) among controls was tested using χ² analysis. Genotype and allele frequencies for variants were compared between groups. Odds ratio (OR) accompanied by 95% confidence interval (CI) reflected the potential link of IL-6 variants to CHD occurrence. RESULTS A remarkable increased trend of rs1800795 CC

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC7301674 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature