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Isolation of infectious SARS-CoV-2 from urine of a COVID-19 patient.

ABSTRACT: SARS-CoV-2 caused a major outbreak of severe pneumonia (COVID-19) in humans. Viral RNA was detected in multiple organs in COVID-19 patients. However, infectious SARS-CoV-2 was only isolated from respiratory specimens. Here, infectious SARS-CoV-2 was successfully isolated from urine of a COVID-19 patient. The virus isolated could infect new susceptible cells and was recognized by its' own patient sera. Appropriate precautions should be taken to avoid transmission from urine.

SUBMITTER: Sun J

PROVIDER: S-EPMC7301718 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Isolation of infectious SARS-CoV-2 from urine of a COVID-19 patient.

Sun Jing J Zhu Airu A Li Heying H Zheng Kui K Zhuang Zhen Z Chen Zhao Z Shi Yongxia Y Zhang Zhaoyong Z Chen Si-Bei SB Liu Xuesong X Dai Jun J Li Xiaobo X Huang Shuxiang S Huang Xiaofang X Luo Ling L Wen Liyan L Zhuo Jianfen J Li Yuming Y Wang Yanqun Y Zhang Lu L Zhang Yanjun Y Li Fang F Feng Liqiang L Chen Xinwen X Zhong Nanshan N Yang Zifeng Z Huang Jicheng J Zhao Jincun J Li Yi-Min YM

Emerging microbes & infections 20201201 1

SARS-CoV-2 caused a major outbreak of severe pneumonia (COVID-19) in humans. Viral RNA was detected in multiple organs in COVID-19 patients. However, infectious SARS-CoV-2 was only isolated from respiratory specimens. Here, infectious SARS-CoV-2 was successfully isolated from urine of a COVID-19 patient. The virus isolated could infect new susceptible cells and was recognized by its' own patient sera. Appropriate precautions should be taken to avoid transmission from urine. ...[more]

PMID: 32342724

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