The type I-E CRISPR-Cas system influences the acquisition of bla_KPC-IncF plasmid in Klebsiella pneumonia.

ABSTRACT: Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) have disseminated worldwide and emerged as major threats to public health. Of epidemiological significance, the international pandemic of KPC-KP is primarily associated with CG258 isolates and bla_KPC-IncF plasmids. CRISPR-Cas system is an adaptive immune system that can hinder gene expansion driven by horizontal gene transfer. Because of bla_KPC-IncF plasmids are favored by CG258 K. pneumoniae, it was of interest to examine the co-distribution of CRISPR and bla_KPC-IncF plasmids in such isolates. We collected 459 clinical K. pneumoniae isolates in China and collected 203 global whole-genome sequences in GenBank to determine the prevalenc

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC7301723 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature