Project description:Non-cystic fibrosis bronchiectasis is a severe respiratory disease characterized by progressive loss of lung function, resulting in high morbidity and even early mortality. Current treatments cannot repair progressive lung damage, which encouraged the exploration of stem and progenitor cell-based regenerative therapies. In current study, we found that the P63+ progenitor cells normally located in airway basal layer could appear in the alveolar spaces of bronchiectasis patients. We successfully cloned and expanded the progenitor cells from the airway brushing tissues of patients. Then we conducted a randomized, single-blind, controlled, phase 1/2 trial to evaluate the safety and efficacy of autologous P63+ progenitor cells transplantation in bronchiectasis patients.

2024-10-15 | GSE261102 | GEO

T6SS: A Key to Pseudomonas's Success in Biocontrol?

Project description: Not available

| S-EPMC10673566 | biostudies-literature

Bronchiectasis Information and Education: a randomised, controlled feasibility trial.

Project description: Not available

| S-EPMC7158127 | biostudies-literature

Feeling matters: perceived social support moderates the relationship between personal relative deprivation and depressive symptoms.

Project description: Not available

| S-EPMC8273951 | biostudies-literature

Randomised controlled trial of nebulised gentamicin in children with bronchiectasis.

Project description: Not available