The Small RNA sr8384 Is a Crucial Regulator of Cell Growth in Solventogenic Clostridia.

ABSTRACT: Small RNAs (sRNAs) are crucial regulatory molecules in organisms and are well-known not only for their roles in the control of diverse crucial biological processes but also for their value in regulation rewiring. However, to date, in Gram-positive anaerobic solventogenic clostridia (a group of important industrial bacteria with exceptional substrate and product diversity), sRNAs remain minimally explored, and thus there is a lack of detailed understanding regarding these important molecules and their use as targets for genetic improvement. Here, we performed large-scale phenotypic screens of a transposon-mediated mutant library of Clostridium acetobutylicum, a typical solventogenic clostridial species, and discovered a novel sRNA (sr8384) that functions as a crucial regulator of cel

SUBMITTER: Yang Y 

PROVIDER: S-EPMC7301862 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature