Personal aging markers and ageotypes revealed by deep longitudinal profiling.

ABSTRACT: The molecular changes that occur with aging are not well understood^1-4. Here, we performed longitudinal and deep multiomics profiling of 106 healthy individuals from 29 to 75 years of age and examined how different types of 'omic' measurements, including transcripts, proteins, metabolites, cytokines, microbes and clinical laboratory values, correlate with age. We identified both known and new markers that associated with age, as well as distinct molecular patterns of aging in insulin-resistant as compared to insulin-sensitive individuals. In a longitudinal setting, we identified personal aging markers whose levels changed over a short time frame of 2-3 years. Further, we defined different types of aging patterns in different individuals, termed 'ageotypes', on the basis of the t

SUBMITTER: Ahadi S 

PROVIDER: S-EPMC7301912 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature