Proteomic analysis in lupus mice identifies Coronin-1A as a potential biomarker for lupus nephritis.

ABSTRACT:

Background

Approximately 50% of systemic lupus erythematosus (SLE) patients develop nephritis, which is among the most severe and frequent complications of the disease and a leading cause of morbidity and mortality. Despite intensive research, there are still no reliable lupus nephritis (LN) markers in clinical use that can assess renal damage and activity with a high sensitivity and specificity. To this end, the aim of this study was to identify new clinically relevant tissue-specific protein biomarkers and possible underlying molecular mechanisms associated with renal involvement in SLE, using mass spectrometry (MS)-based proteomics.

Methods

Kidneys were harvested from female triple congenic B6.NZMsle1/sle2/sle3 lupus mice model, and the respective sex- and age-matched C57

SUBMITTER: Nicolaou O 

PROVIDER: S-EPMC7301983 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature