Immunohistochemical expression of Cyclin D1 among Sudanese patients diagnosed with benign and malignant prostatic lesions.

ABSTRACT:

Objectives

Prostate cancer (PC) is common cancer worldwide. Several markers have been developed to differentiate between benign prostatic hyperplasia (BPH) from PC. A descriptive retrospective hospital-based study aimed at determining the expression of Cyclin D1 in BPH and PC. The study took place at different histopathology laboratories in Khartoum state, Sudan, from December 2016 to January 2019. Formalin-fixed paraffin-embedded blocks were sectioned and fixed in 3-aminopropyltriethoxysilane coated slides incubated into primary antibody for Cyclin D1. The assessment of immunoreactivity of Cyclin D1 of each section was done using the Gleason scoring system.

Results

A total of 153 males' prostate sections included in this study, of them, 120 (78.4%) were PC, and 33 (21.6%) w

SUBMITTER: Ahmed ES 

PROVIDER: S-EPMC7302005 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature