Age-Related Differences in the Gut Microbiome of Rhesus Macaques.

ABSTRACT: Aging is a multifactorial process characterized by progressive changes in gut physiology and the intestinal mucosal immune system. These changes, along with alterations in lifestyle, diet, nutrition, inflammation and immune function alter both composition and stability of the gut microbiota. Given the impact of environmental influences on the gut microbiota, animal models are particularly useful in this field. To understand the relationship between the gut microbiota and aging in nonhuman primates, we collected fecal samples from 20 male and 20 female rhesus macaques (Macaca mulatta), across the natural macaque age range, for 16S rRNA gene analyses. Operational taxonomic units were then grouped together to summarize taxon abundance at different hierarchical levels of classification and alp

SUBMITTER: Adriansjach J 

PROVIDER: S-EPMC7302168 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature