On the Definition of Sarcopenia in the Presence of Aging and Obesity-Initial Results from UK Biobank.

ABSTRACT:

Background

Current consensus is to combine a functional measure with muscle quantity to assess/confirm sarcopenia. However, the proper body size adjustment for muscle quantity is debated and sarcopenia in obesity is not well described. Further, functional measures are not muscle-specific or sensitive to etiology, and can be confounded by, for example, fitness/pain. For effective detection/treatment/follow-up, muscle-specific biomarkers linked to function are needed.

Methods

Nine thousand six hundred and fifteen participants were included and current sarcopenia thresholds (EWGSOP2: DXA, hand grip strength) applied to investigate prevalence. Fat-tissue free muscle volume (FFMV) and muscle fat infiltration (MFI) were quantified through magnetic resonance imaging (MRI) and sex-a

SUBMITTER: Linge J 

PROVIDER: S-EPMC7302181 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature