Landscape and Selection of Vaccine Epitopes in SARS-CoV-2.

ABSTRACT: There is an urgent need for a vaccine with efficacy against SARS-CoV-2. We hypothesize that peptide vaccines containing epitope regions optimized for concurrent B cell, CD4⁺ T cell, and CD8⁺ T cell stimulation would drive both humoral and cellular immunity with high specificity, potentially avoiding undesired effects such as antibody-dependent enhancement (ADE). Additionally, such vaccines can be rapidly manufactured in a distributed manner. In this study, we combine computational prediction of T cell epitopes, recently published B cell epitope mapping studies, and epitope accessibility to select candidate peptide vaccines for SARS-CoV-2. We begin with an exploration of the space of possible T cell epitopes in SARS-CoV-2 with interrogation of predicted HLA-I and HLA-I

SUBMITTER: Smith CC 

PROVIDER: S-EPMC7302209 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature