Crosstalk between Neospora caninum and the bovine host at the maternal-foetal interface determines the outcome of infection.

ABSTRACT: Neospora caninum is an apicomplexan cyst-forming parasite that is considered one of the main causes of abortion. The pathogenic mechanisms associated with parasite virulence at the maternal-foetal interface that are responsible for the outcome of infection are largely unknown. Here, utilizing placentomes from cattle experimentally infected with high-virulence (Nc-Spain7) and low-virulence (Nc-Spain1H) isolates, we studied key elements of the innate and adaptive immune responses, as well as components of the extracellular matrix (ECM), at 10 and 20 days post-infection (dpi). The low-virulence isolate elicited a robust immune response characterized by upregulation of genes involved in pathogen recognition, chemokines and pro-inflammatory cytokines, crucial for its adequate control. In additi

SUBMITTER: Jimenez-Pelayo L 

PROVIDER: S-EPMC7302351 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature