Preclinical anticancer studies on the ethyl acetate leaf extracts of Datura stramonium and Datura inoxia.

ABSTRACT:

Background

Cancer is a horrific disease relentlessly affecting human population round the globe. Genus Datura encompasses numerous species with reported medicinal uses. However, its potential as a source of natural anticancer agents is yet to be determined. Datura stramonium (DS) and Datura inoxia (DI) are the two species chosen for this study.

Methods

Total phenolic and flavonoid content (TPC and TFC) as well as antioxidant activity were assessed through colorimetric method. Polyphenolic quantification was done by RP-HPLC. Following extract standardization ethyl acetate leaf extracts of both species (DSL-EA and DIL-EA) were chosen for anticancer studies. In vitro cytotoxicity using various models including cancer cell lines was monitored. Following toxicity studies, benzene

SUBMITTER: Nasir B 

PROVIDER: S-EPMC7302377 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature