Water-Soluble BODIPY Photocages with Tunable Cellular Localization.

ABSTRACT: Photoactivation of bioactive molecules allows manipulation of cellular processes with high spatiotemporal precision. The recent emergence of visible-light excitable photoprotecting groups has the potential to further expand the established utility of the photoactivation strategy in biological applications by offering higher tissue penetration, diminished phototoxicity, and compatibility with other light-dependent techniques. Nevertheless, a critical barrier to such applications remains the significant hydrophobicity of most visible-light excitable photocaging groups. Here, we find that applying the conventional 2,6-sulfonation to meso-methyl BODIPY photocages is incompatible with their photoreaction due to an increase in the excited state barrier for photorelease. We present a simpl

SUBMITTER: Kand D 

PROVIDER: S-EPMC7302507 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature