Temporal Lobe Necrosis in Head and Neck Cancer Patients after Proton Therapy to the Skull Base.

ABSTRACT:

Purpose

To demonstrate temporal lobe necrosis (TLN) rate and clinical/dose-volume factors associated with TLN in radiation-naïve patients with head and neck cancer treated with proton therapy where the field of radiation involved the skull base.

Materials and methods

Medical records and dosimetric data for radiation-naïve patients with head and neck cancer receiving proton therapy to the skull base were retrospectively reviewed. Patients with <3 months of follow-up, receiving <45 GyRBE or nonconventional fractionation, and/or no follow-up magnetic resonance imaging (MRI) were excluded. TLN was determined using MRI and graded using Common Terminology Criteria for Adverse Events (CTCAE) v5.0. Clinical (gender, age, comorbidities, concurrent chemotherapy, smoking, radiation tec

SUBMITTER: Kitpanit S 

PROVIDER: S-EPMC7302730 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature