Human MAIT cell cytolytic effector proteins synergize to overcome carbapenem resistance in Escherichia coli.

ABSTRACT: Mucosa-associated invariant T (MAIT) cells are abundant antimicrobial T cells in humans and recognize antigens derived from the microbial riboflavin biosynthetic pathway presented by the MHC-Ib-related protein (MR1). However, the mechanisms responsible for MAIT cell antimicrobial activity are not fully understood, and the efficacy of these mechanisms against antibiotic resistant bacteria has not been explored. Here, we show that MAIT cells mediate MR1-restricted antimicrobial activity against Escherichia coli clinical strains in a manner dependent on the activity of cytolytic proteins but independent of production of pro-inflammatory cytokines or induction of apoptosis in infected cells. The combined action of the pore-forming antimicrobial protein granulysin and the serine protease granzy

SUBMITTER: Boulouis C 

PROVIDER: S-EPMC7302869 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature