Intrinsic connectomes are a predictive biomarker of remission in major depressive disorder.

ABSTRACT: Although major depressive disorder (MDD) is associated with altered functional coupling between disparate neural networks, the degree to which such measures are ameliorated by antidepressant treatment is unclear. It is also unclear whether functional connectivity can be used as a predictive biomarker of treatment response. Here, we used whole-brain functional connectivity analysis to identify neural signatures of remission following antidepressant treatment, and to identify connectomic predictors of treatment response. 163 MDD and 62 healthy individuals underwent functional MRI during pre-treatment baseline and 8-week follow-up sessions. Patients were randomized to escitalopram, sertraline or venlafaxine-XR antidepressants and assessed at follow-up for remission. Baseline measures of intri

SUBMITTER: Korgaonkar MS 

PROVIDER: S-EPMC7303006 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature