Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort.

ABSTRACT: While comorbidity between coronary heart disease (CHD) and depression is evident, it is unclear whether the two diseases have shared underlying mechanisms. We performed a range of analyses in 367,703 unrelated middle-aged participants of European ancestry from UK Biobank, a population-based cohort study, to assess whether comorbidity is primarily due to genetic or environmental factors, and to test whether cardiovascular risk factors and CHD are likely to be causally related to depression using Mendelian randomization. We showed family history of heart disease was associated with a 20% increase in depression risk (95% confidence interval [CI] 16-24%, p < 0.0001), but a genetic risk score that is strongly associated with CHD risk was not associated with depression. An increase of 1 standard

SUBMITTER: Khandaker GM 

PROVIDER: S-EPMC7303009 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature