E-vapor aerosols do not compromise bone integrity relative to cigarette smoke after 6-month inhalation in an ApoE^-/- mouse model.

ABSTRACT: Cigarette smoke (CS) exposure is one of the leading risk factors for human health. Nicotine-containing inhalable products, such as e-cigarettes, can effectively support tobacco harm reduction approaches. However, there are limited comparative data on the effects of the aerosols generated from electronic vapor products (e-vapor) and CS on bone. Here, we report the effects of e-vapor aerosols and CS on bone morphology, structure, and strength in a 6-month inhalation study. Eight-week-old ApoE^-/- mice were exposed to aerosols from three different e-vapor formulations-CARRIER (propylene glycol and vegetable glycerol), BASE (CARRIER and nicotine), TEST (BASE and flavor)-to CS from 3R4F reference cigarettes at matched nicotine concentrations (35 µg/L) or to fresh air (Sham) (N = 10 pe

SUBMITTER: Reumann MK 

PROVIDER: S-EPMC7303066 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature