Regulatory T cells specifically suppress conventional CD8αβ T cells in intestinal tumors of APC^Min/+ mice.

ABSTRACT: The presence of activated T cells in colorectal cancer tissues is a strong predictor of patient survival. Our previous studies have shown that regulatory T cells (Treg) are able to reduce T cell transendothelial migration in vitro and accumulation of effector T cells in intestinal tumors in vivo in the murine APC^Min/+ model for microsatellite stable intestinal tumors. In this study, we investigated the effect of Treg depletion on the density and effector functions of different TCRαβ⁺ and TCRγδ⁺ T cell populations in intestinal tumors. We used the APC^Min/+\DEREG mouse model, which harbor a diphtheria toxin receptor under the control of the FOXP3 promoter, to deplete Treg in tumor bearing mice. We found that the density of conventional TCRαβ^+<

SUBMITTER: Szeponik L 

PROVIDER: S-EPMC7303072 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature