Ontology highlight
ABSTRACT:
SUBMITTER: Van der Auwera P
PROVIDER: S-EPMC7303124 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Van der Auwera Petrus P Frooninckx Lotte L Buscemi Kristen K Vance Ryan T RT Watteyne Jan J Mirabeau Olivier O Temmerman Liesbet L De Haes Wouter W Fancsalszky Luca L Gottschalk Alexander A Raizen David M DM Nelson Matthew D MD Schoofs Liliane L Beets Isabel I
Scientific reports 20200618 1
Sleep and wakefulness are fundamental behavioral states of which the underlying molecular principles are becoming slowly elucidated. Transitions between these states require the coordination of multiple neurochemical and modulatory systems. In Caenorhabditis elegans sleep occurs during a larval transition stage called lethargus and is induced by somnogenic neuropeptides. Here, we identify two opposing neuropeptide/receptor signaling pathways: NLP-22 promotes behavioral quiescence, whereas NLP-2 ...[more]