Static and dynamic functional connectivity analysis of cerebrovascular reactivity: An fMRI study.

ABSTRACT:

Background

Cerebrovascular reactivity (CVR) is an important aspect of brain function, and as such it is important to understand relationship between CVR and functional connectivity.

Methods

This research studied the role of CVR, or the brain's ability to react to vasoactive stimuli on brain functional connectivity by scanning subjects with blood-oxygenation-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) while they periodically inhale room air and a CO 2-enriched gas mixture. We developed a new metric to measure the effect of CVR on each intrinsic connectivity network (ICN), which contrasts to voxel-wise CVR. We also studied the changes in whole-brain connectivity patterns using both static functional network connectivity (sFNC) and dynamic FNC (dFNC).

SUBMITTER: Lewis N 

PROVIDER: S-EPMC7303385 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature