The trajectory of gait development in mice.

ABSTRACT:

Objective

Gait irregularities are prevalent in neurodevelopmental disorders (NDDs). However, there is a paucity of information on gait phenotypes in NDD experimental models. This is in part due to the lack of understanding of the normal developmental trajectory of gait maturation in the mouse.

Materials and methods

Using the DigiGait system, we have developed a quantitative, standardized, and reproducible assay of developmental gait metrics in commonly used mouse strains that can be added to the battery of mouse model phenotyping. With this assay, we characterized the trajectory of gait in the developing C57BL/6J and FVB/AntJ mouse lines.

Results

In both lines, a mature stride consisted of 40% swing and 60% stance in the forelimbs, which mirrors the mature human strid

SUBMITTER: Akula SK 

PROVIDER: S-EPMC7303394 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature