Reliability of multimodal MRI brain measures in youth at risk for mental illness.

ABSTRACT:

Introduction

A new generation of large-scale studies is using neuroimaging to investigate adolescent brain development across health and disease. However, imaging artifacts such as head motion remain a challenge and may be exacerbated in pediatric clinical samples. In this study, we assessed the scan-rescan reliability of multimodal MRI in a sample of youth enriched for risk of mental illness.

Methods

We obtained repeated MRI scans, an average of 2.7 ± 1.4 weeks apart, from 50 youth (mean age 14.7 years, SD = 4.4). Half of the sample (52%) had a diagnosis of an anxiety disorder; 22% had attention-deficit/hyperactivity disorder (ADHD). We quantified reliability with the test-retest intraclass correlation coefficient (ICC).

Results

Gray matter measurements were highly r

SUBMITTER: Drobinin V 

PROVIDER: S-EPMC7303399 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature