Effect of time to surgery on outcomes in stage I esophageal adenocarcinoma.

ABSTRACT:

Background

There are limited data on the safe interval from diagnosis to surgery in patients with stage I esophageal adenocarcinoma. We hypothesized that increased time to surgery would be associated with worse survival and increased nodal upstaging.

Methods

The National Cancer Database was used to identify patients with cT1N0M0 esophageal adenocarcinoma (2004-2015) who underwent esophagectomy without induction therapy. The primary outcome was survival, and the secondary outcomes were the rate of margin-positive resection and pathologic nodal upstaging. Time to surgery was modeled as a categoric variable, dividing patients into quartiles (Q1-4), and as a continuous variable using piecewise linear splines centered on 50 and 100 days.

Results

A total of 2495 patients me

SUBMITTER: Raman V 

PROVIDER: S-EPMC7303510 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature