Role of FOXM1 in vascular smooth muscle cell survival and neointima formation following vascular injury.

ABSTRACT:

Background

Accelerated smooth muscle cell (SMC) proliferation is the primary cause of intimal hyperplasia (IH) following vascular interventions. Forkhead Box M1 (FOXM1) is considered a proliferation-associated transcription factor. However, the presence and role of FOXM1 in IH following vascular injury have not been determined.

Objective

We examined the expression of FOXM1 in balloon-injured rat carotid arteries and investigated the effect of FOXM1 inhibition in SMCs and on the development of IH.

Methods and results

FOXM1 was detected by immunofluorescent staining in balloon-injured rat carotid arteries where we observed an upregulation at day 7, 14, and 28 compared to uninjured controls. Immunofluorescence staining revealed FOXM1 coincided with proliferating cell nuc

SUBMITTER: Franco S 

PROVIDER: S-EPMC7303564 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature