Ontology highlight
ABSTRACT:
SUBMITTER: Huo J
PROVIDER: S-EPMC7303615 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Cell host & microbe 20200619 3
There are as yet no licensed therapeutics for the COVID-19 pandemic. The causal coronavirus (SARS-CoV-2) binds host cells via a trimeric spike whose receptor binding domain (RBD) recognizes angiotensin-converting enzyme 2, initiating conformational changes that drive membrane fusion. We find that the monoclonal antibody CR3022 binds the RBD tightly, neutralizing SARS-CoV-2, and report the crystal structure at 2.4 Å of the Fab/RBD complex. Some crystals are suitable for screening for entry-blocki ...[more]