Variations in the cerebrospinal fluid proteome following traumatic brain injury and subarachnoid hemorrhage.

ABSTRACT:

Background

Proteomic analysis of cerebrospinal fluid (CSF) has shown great promise in identifying potential markers of injury in neurodegenerative diseases [1-13]. Here we compared CSF proteomes in healthy individuals, with patients diagnosed with traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH) in order to characterize molecular biomarkers which might identify these different clinical states and describe different molecular mechanisms active in each disease state.

Methods

Patients presenting to the Neurosurgery service at the Louisiana State University Hospital-Shreveport with an admitting diagnosis of TBI or SAH were prospectively enrolled. Patients undergoing CSF sampling for diagnostic procedures were also enrolled as controls. CSF aliquots were subjected t

SUBMITTER: Connor DE 

PROVIDER: S-EPMC7303909 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature