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Letter to the editor: efficacy of different methods of combination regimen administrations including dexamethasone, intravenous immunoglobulin, and interferon-beta to treat critically ill COVID-19 patients: a structured summary of a study protocol for a randomized controlled trial.


ABSTRACT:

SUBMITTER: Abdolahi N 

PROVIDER: S-EPMC7303932 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Letter to the editor: efficacy of different methods of combination regimen administrations including dexamethasone, intravenous immunoglobulin, and interferon-beta to treat critically ill COVID-19 patients: a structured summary of a study protocol for a randomized controlled trial.

Abdolahi Nafiseh N   Kaheh Effat E   Golsha Roghieh R   Khodabakhshi Behnaz B   Norouzi Alireza A   Khandashpoor Mahmoud M   Besharat Sima S   Tavassoli Samane S   Livani Somayeh S   Azimi Sadegh Ali SA   Gharib Mohammad Hadi MH   Peivandi Babak B   Fazel Abdolreza A   Shirzad-Aski Hesamaddin H   Roshandel Gholamreza G  

Trials 20200619 1


<h4>Objectives</h4>There is little information about Coronavirus Disease 2019 (COVID-19) management for critically ill patients. Most of these patients develop acute respiratory distress syndrome (ARDS) due to excessive inflammatory response and the ensuing cytokine storm. Anti-inflammatory drugs including corticosteroids can be used to effectively reduce the effect of this cytokine storm and lung damage. However, corticosteroids can have side effects, so simultaneous administration of immunoglo  ...[more]

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