Coarse-Grained Molecular Model for the Glycosylphosphatidylinositol Anchor with and without Protein.

ABSTRACT: Glycosylphosphatidylinositol (GPI) anchors are a unique class of complex glycolipids that anchor a great variety of proteins to the extracellular leaflet of plasma membranes of eukaryotic cells. These anchors can exist either with or without an attached protein called GPI-anchored protein (GPI-AP) both in vitro and in vivo. Although GPIs are known to participate in a broad range of cellular functions, it is to a large extent unknown how these are related to GPI structure and composition. Their conformational flexibility and microheterogeneity make it difficult to study them experimentally. Simplified atomistic models are amenable to all-atom computer simulations in small lipid bilayer patches but not suitable for studying their partitioning and trafficking in complex and hete

SUBMITTER: Banerjee P 

PROVIDER: S-EPMC7303967 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature