Genetic risk factors for venous thromboembolism among infertile men with Klinefelter syndrome.

ABSTRACT:

Background

Klinefelter syndrome (KS) is one of the commonest sex chromosome disorders. Affected males become infertile and highly susceptible to several health problems, including vascular thromboembolism (VTE). The risk of VTE may be exacerbated by an underlying genetically inherited thrombophilia. In this study, we aimed to investigate the genotype and allele frequencies of common gene polymorphisms related to hereditary thrombophilia in infertile males with KS compared to normal, fertile men.

Methods

Eighty-five infertile males with KS and 75 healthy control males were included in this case-control study. Genetic testing was done using an extended thrombophilia gene panel by Multiplex PCR reverse hybridization method.

Results

There was an increased frequency of mut

SUBMITTER: Hussein TM 

PROVIDER: S-EPMC7303976 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature