β-Turn Mimics by Chemical Ligation.

ABSTRACT: We report a simple reductive amination protocol to ligate two peptides, while simultaneously installing a β-turn mimic at the ligation junction. This strategy uses commercially available materials, mild chemical conditions, and a chemoselective ligation reaction of unprotected peptide substrates accessed through standard solid phase methods. This system was implemented in a designed β-hairpin system, and biophysical analysis demonstrates effective mimicry of the β-turn.

SUBMITTER: Crecente-Garcia S 

PROVIDER: S-EPMC7304061 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature