MiRNA155HG polymorphisms influenced the risk of liver cancer among the Han Chinese population.

ABSTRACT:

Background

Liver cancer is one of the most common cancers in the world. The primary aim of this research was to discover the correlation between single nucleotide polymorphisms (SNPs) of the MIR155HG and liver cancer risk.

Methods

The selected SNPs in MIR155HG were genotyped utilizing the Agena MassARRAY platform. We evaluated the correlation between MIR155HG polymorphisms and Liver cancer by genetic model analysis, stratification analysis and haplotype analysis. Relative risk of Liver cancer was shown based on odds ratios (ORs) and 95% confidence intervals (95% CIs).

Results

Our results uncovered that rs12482371 and rs1893650 in the MIR155HG were associated with protection against Liver cancer. And the rs928883 was related to increase risk of Liver cancer. Furthermor

SUBMITTER: Chao X 

PROVIDER: S-EPMC7304092 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature