The neuro-pathophysiology of temporomandibular disorders-related pain: a systematic review of structural and functional MRI studies.

ABSTRACT: Chronic pain surrounding the temporomandibular joints and masticatory muscles is often the primary chief complaint of patients with temporomandibular disorders (TMD) seeking treatment. Yet, the neuro-pathophysiological basis underlying it remains to be clarified. Neuroimaging techniques have provided a deeper understanding of what happens to brain structure and function in TMD patients with chronic pain. Therefore, we performed a systematic review of magnetic resonance imaging (MRI) studies investigating structural and functional brain alterations in TMD patients to further unravel the neurobiological underpinnings of TMD-related pain. Online databases (PubMed, EMBASE, and Web of Science) were searched up to August 3, 2019, as complemented by a hand search in reference lists. A total of 62

SUBMITTER: Yin Y 

PROVIDER: S-EPMC7304152 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature