Prognostic characterization of OAS1/OAS2/OAS3/OASL in breast cancer.

ABSTRACT:

Background

Prognostic biomarkers remain a focus in breast cancer during last decades. More reliable predictors to adequately characterize the prognosis of breast cancer are essential. The 2'-5'-oligoadenylate synthetases (OAS), composing of OAS1, OAS2, OAS3, and OAS-like (OASL), are interferon (IFN)-induced antiviral enzymes, with their prognostic roles remain to be characterized.

Methods

Prognostic values of OAS family members were assessed by multiple public available resources.

Results

High mRNA expression of OAS1 and OAS3 were correlated with worse prognosis for all breast cancer patients, whereas OAS2 was associated with favorable prognosis. The prognostic values of OAS family in different clinicopathologic subtypes were also characterized. In DNA methylation lev

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC7304174 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature