T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles.

ABSTRACT:

Background

Asthma is a common and heterogeneous disease that includes subgroups characterized by type 2 (T2) or type 17 (T17) immune responses for which there is a need to identify the underlying mechanisms and biomarkers in order to develop specific therapies. These subgroups can be defined by airway epithelium gene signatures and the airway epithelium has also been implicated to play a significant role in asthma pathology. Extracellular vesicles (EVs) carry functional biomolecules and participate in cell-to-cell communication in both health and disease, properties that are likely to be involved in airway diseases such as asthma. The aim of this study was to identify stimulus-specific proteins and functionality of bronchial epithelium-derived EVs following stimulation with T2 or T

SUBMITTER: Ax E 

PROVIDER: S-EPMC7304225 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature