Photocatalytic Oxidative Dearomatization of Orcinaldehyde Derivatives.

ABSTRACT: For decades, oxidative dearomatization has been employed as a key step in the synthesis of complex molecules. Challenges in controlling the chemo- and site-selectivity of this transformation have sparked the development of a variety of specialized oxidants; however, these result in stoichiometric amounts of organic byproducts. Herein, we describe a photocatalytic method for oxidative dearomatization using molecular oxygen as the stoichiometric oxidant. This provides environmentally benign entry to highly substituted o-quinols, reactive intermediates which can be elaborated to a number of natural product families.

SUBMITTER: Baker Dockrey SA 

PROVIDER: S-EPMC7304345 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature